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Our synthesis capabilities include preparation of small libraries, cores, scaffolds and building blocks. We also provide synthesis support in the preparation of advanced intermediates, reference compounds and impurities.
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Key
reaction capabilities
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| Acylation |
Hydrogenation |
| Alkylation |
Leuckart reaction |
| Amidation |
Mannich reaction |
| Aminoacid
derivatives |
Mitsunobu
reaction |
| Buchwald reaction |
Oligo-peptide synthesis |
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Claisen reaction |
Oxidations
/ reductions |
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Curtius rearrangement |
Reductive
amination |
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Cyanation |
Reformatsky
reaction |
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Darzens reaction |
Stille
coupling |
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Friedel Crafts alkylation /
acylation |
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Fries migration |
Suzuki
coupling |
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Grignard reaction |
Ullman reaction |
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Halogenation |
Williamson synthesis |
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Heck reaction |
Wittig reaction |
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Special expertise offered in areas like
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| Synthesis of
chiral building blocks and
intermediates |
| Small size aromatic & aliphatic compounds |
| Heterocyclic chemistry |
| Protection of amino acids at amino and carboxyl functionalities |
| Asymmetric synthesis |
| Bridged
piperazines |
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List of Scientific
Publications |
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An improved synthesis of
N-aryl and N-heteroaryl substituted
piperidones
Tetrahedron Letters Volume 48, Issue
14, 2 April 2007, Pages 2519-2525
Uwe Schöna,
Josef Messingera,
M. Buckendahla,
M.S. Prabhub
and A. Kondab
a - Solvay Pharmaceuticals Research
Laboratories, Hans-Böckler-Allee 20, 30173
Hannover, Germany
b - Research Support International
Limited, S.V. Road, Majiwada, Thane West
400 610, India
Abstract : An efficient Pd(0)-catalyzed
protocol for the rapid and efficient
preparation of N-aryl and N-heteroaryl
substituted piperidones is described. The
two step syntheses proceed with an overall
yield of 50–70% using X-Phos as optimal
ligand for the Pd(0)-catalyzed Buchwald–Hartwig
amination followed by subsequent
hydrolysis of resulted ketals.
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An improved synthesis of
3-aminoestrone
Tetrahedron Letters Volume 46, Issue
42, 17 October 2005, Pages 7111-7115
Uwe Schöna,
Josef Messingera,
Monika Buchholza,
Uwe Reineckera,
Hubert Tholea,
M.S. Prabhub
and A. Kondab
a - Solvay Pharmaceuticals Research
Laboratories, Hans-Böckler-Allee 20, 30173
Hannover, Germany
b - Research Support International
Limited, S.V. Road, Majiwada, Thane West
400 610, India
Abstract : An efficient Pd(0)-catalyzed
protocol for the rapid and efficient
preparation of 3-aminoestrone via
3-benzylaminoestrone from estrone–triflate
is described. The three step synthesis
proceeds with an overall yield of about
55% using X-Phos as optimal ligand for the
Pd(0)-catalyzed Buchwald–Hartwig amination.
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Research
Support International Limited
(A wholly owned subsidiary of DIL Ltd.)
Copyright 2005-08. All Rights Reserved.
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"Success is the maximum utilization of the ability that you
have".- Zig Ziglar |
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Publications |
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An
improved synthesis of N-aryl and N-heteroaryl
substituted piperidones
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An
improved synthesis of 3-aminoestrone
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Our Capabilities |
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Multistep synthesis in multigram :
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Natural product like scaffolds, Heterocyclic
Scaffolds, Building blocks, Reference
Compounds, Impurities
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Focussed library using parallel synthesis and
automated purification technique
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Route scouting & Process optimization
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Scale-up of deliverables (1 gm to 25 kg)
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Analytical Method Development & Testing
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Project Management |
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Dedicated Manager
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Proactive communication
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Implementation of high priority project /
synthesis
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Receptive to change of priorities of work plan
from customers
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Weekly update / Biweekly Report / Tele
Conference
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Video conference upon mutual agreement
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Other Attributes |
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